The M3K13 Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to MLK. This antibody recognizes Human, Mouse, and Rat antigen. The M3K13 Antibody has been validated for the following applications: Western Blot.
Description
Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. Acts synergistically with PRDX3 to regulate the activation of NF-kappa-B in the cytosol. This activation is kinase-dependent and involves activating the IKK complex, the IKBKB-containing complex that phosphorylates inhibitors of NF-kappa-B.Sakuma H., J. Biol. Chem. 272:28622-28629(1997).Schultz S.J., Cell Growth Differ. 4:821-830(1993).Ikeda A., FEBS Lett. 488:190-195(2001)